Harnessing Chemoselectivity to Drive Innovation
Moving Medicinal Chemistry Forward
We are here to improve the ways we synthesize, identify, and assess medicinally-relevant small molecule and peptide entities. Projects in the Buonomo Lab span the gamut of early-stage drug development campaigns from target identification and validation to new chemical entity assessment in simple biological model systems.
Better Amino Acid-Specific Chemistries
From new bioconjugation chemistries to proteome-wide protein sequencing. We’re developing amino acid-specific chemistries with defined site-specificity based on peptide/protein sequence or high chemoselectivity for key residues regardless of sequence. These technologies enable the creation of novel therapeutics and diagnostics.
Chemical Bacteriology
Our research enables basic biological study of bacteria. We’re particularly interested in furthering our knowledge of host-pathogen interactions of bacterial lipids from pathogens such as M. tuberculosis. These projects utilize bioorthogonal chemistry to enable labeling of these lipids with fluorescent molecules and trifunctional probes to enable studies ranging from microscopy to proteomics.
Creating an Inclusive Space
The Buonomo Lab is committed to performing basic scientific research and translating those findings to the development of new technologies that serve humanity. Our endeavors are supported by the next generation of scientists which include researchers of all races, ethnicities, sexual orientations, gender identities, and abilities. We foster a safe and open space in which everyone is valued, we can all learn from each other, and where we take action to challenge systematic inequalities in science.